Analysis of Anti-infective agents
INTRODUCTION
Anti-infectives are a class of many types of drugs that cover a broad range of infections, including antibiotics, antifungals, antiviral, and even protozoal infections. They have different mechanisms of action based on pathogens transmission and interaction with their host. Column ASTRA® allows to separate a broad spectrum of anti-infectives with a completely different chemical structure.
ABSTRACT
LC-MS full-scan determination of 13 anti-infective agents of different chemical classes on an ASTRA® C18-HE 3.0 µm column, 75 mm × 2.1 mm, part number AST-5732-IH21. Mobile phase A is DDW + 0.1% formic acid and mobile phase B is ACN + 0.1% formic acid. Gradient elution (time / A% / B%): 0 / 90 / 10, 1 / 90 / 10, 4 / 75 / 25, 8 / 60 / 40, 10 / 0 / 100, 14 / 0 / 100, 14.01 / 90 / 10, 15 / 90 / 10, 17 / 90 / 10. Flow rate 0.35 mL/min, column temperature 23 °C, injection volume 5 µL, detection by full scan (resolving power 120 000 at m/z 200) in positive mode. Analytes with CAS numbers as printed in the note: 1. trimethoprim 738-70-5, 2. sulfadimethoxine 122-11-2, 3. sulfaquinoxaline 59-40-5, 4. miconazole 59-40-5, 5. oseltamivir 196618-13-0, 6. oseltamivir acid 187227-45-8, 7.…
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Astra C18-HE
Part number
AST-5732-IH21
Analytes
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- Fluconazole CAS number 86386-73-4
- Clindamycin CAS number 18323-44-9
- Clindamycin Sulfoxide CAS number 22431-46-5
