Cardiovascular drugs
INTRODUCTION
A gradient LC/MS method was developed for rapid determination of several classes of cardiovascular drugs such as non-cardioselective beta blockers, potassium-sparing diuretics, statins, nucleoside transport inhibitors, calcium channel blockers, ACE inhibitors, ARBs, lipid-lowering agents and anticoagulants.
ABSTRACT
Gradient LC-MS determination of 22 cardiovascular drugs of several classes (beta blockers, potassium-sparing diuretics, statins, nucleoside transport inhibitors, calcium channel blockers, ACE inhibitors, ARBs, lipid-lowering agents and anticoagulants) on an ASTRA® C18-HE 3.0 µm column, 75 mm × 2.1 mm, part number AST-5732-IH21. Mobile phase A is DDW + 0.1% formic acid and mobile phase B is ACN + 0.1% formic acid. Gradient elution (time / A% / B%): 0 / 90 / 10, 1 / 90 / 10, 4 / 75 / 25, 8 / 60 / 40, 10 / 0 / 100, 14 / 0 / 100, 14.01 / 90 / 10, 15 / 90 / 10, 17 / 90 / 10. Flow rate 0.35 mL/min, column temperature 23 °C, injection volume 5 µL, detection by full scan (resolving power 120 000 at m/z 200) in positive mode. Analytes with CAS numbers as printed: 1. atenolol 29122-68-7,…
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Astra C18-HE
Part number
AST-5732-IH21
Analytes
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- Atenolol CAS number 29122-68-7
- Sotalol CAS number 3930-20-9
- Triamterene CAS number 396-01-0
- Metoprolol CAS number 51384-51-1
- Metoprolol acid CAS number 56392-14-4
- Rosuvastatin CAS number 287714-41-4
- Propranolol CAS number 525-66-6
- Dipyridamole CAS number 58-32-2
- Diltiazem CAS number 42399-41-7
- Flecainide CAS number 54143-55-4
