CNS-agents-monitoring
INTRODUCTION
There are many different types of drugs that affect the central nervous system (CNS), including anesthetics, anticonvulsants, antiemetics, antiparkinson agents, CNS stimulants, muscle relaxants, narcotic analgesics and sedatives. Their control is important for therapeutic monitoring and in toxicologic purposes. The developed LC/MS method provides the accurate determination of a wide range of CNS agents.
ABSTRACT
LC-MS full-scan determination of a wide panel of 48 central nervous system (CNS) agents (anaesthetics, anticonvulsants, antiemetics, antiparkinson agents, CNS stimulants, muscle relaxants, narcotic analgesics and sedatives) on an ASTRA® C18-HE 3.0 µm column, 75 mm × 2.1 mm, part number AST-5732-IH21. Mobile phase A is DDW + 0.1% formic acid and mobile phase B is ACN + 0.1% formic acid. Gradient elution (time / A% / B%): 0 / 90 / 10, 1 / 90 / 10, 4 / 75 / 25, 8 / 60 / 40, 10 / 0 / 100, 14 / 0 / 100, 14.01 / 90 / 10, 15 / 90 / 10, 17 / 90 / 10. Flow rate 0.35 mL/min, column temperature 23 °C, injection volume 5 µL, detection by full scan (resolving power 120 000 at m/z 200) in positive mode. Analytes with CAS numbers as printed: 1. gabapentin 60142-96-3, 2. terbutaline 23031-25-6,…
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Astra C18-HE
Part number
AST-5732-IH21
Analytes
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- Sertraline CAS number 79617-96-2
- Chlorpromazine CAS number 50-53-3
- Chlorprothixene CAS number 113-59-7
- Clomipramine CAS number 303-49-1
- Clonazepam CAS number 1622-61-3
- Loperamide CAS number 53179-11-6
- Clemastine CAS number 15686-51-8
- Dicycloverine (dicyclomine) CAS number 77-19-0
- Meclizine CAS number 569-65-3
- Alprazolam CAS number 28981-97-7
