CNS-agents-monitoring
INTRODUCTION
There are many different types of drugs that affect the central nervous system (CNS), including anesthetics, anticonvulsants, antiemetics, antiparkinson agents, CNS stimulants, muscle relaxants, narcotic analgesics and sedatives. Their control is important for therapeutic monitoring and in toxicologic purposes. The developed LC/MS method provides the accurate determination of a wide range of CNS agents.
ABSTRACT
LC-MS full-scan determination of a wide panel of 48 central nervous system (CNS) agents (anaesthetics, anticonvulsants, antiemetics, antiparkinson agents, CNS stimulants, muscle relaxants, narcotic analgesics and sedatives) on an ASTRA® C18-HE 3.0 µm column, 75 mm × 2.1 mm, part number AST-5732-IH21. Mobile phase A is DDW + 0.1% formic acid and mobile phase B is ACN + 0.1% formic acid. Gradient elution (time / A% / B%): 0 / 90 / 10, 1 / 90 / 10, 4 / 75 / 25, 8 / 60 / 40, 10 / 0 / 100, 14 / 0 / 100, 14.01 / 90 / 10, 15 / 90 / 10, 17 / 90 / 10. Flow rate 0.35 mL/min, column temperature 23 °C, injection volume 5 µL, detection by full scan (resolving power 120 000 at m/z 200) in positive mode. Analytes with CAS numbers as printed: 1. gabapentin 60142-96-3, 2. terbutaline 23031-25-6,…
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Astra C18-HE
Part number
AST-5732-IH21
Analytes
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- Desmethylcitalopram CAS number 62498-67-3
- Citalopram CAS number 59729-33-8
- Mianserin CAS number 24219-97-4
- Haloperidol CAS number 52-86-8
- Paroxetine CAS number 61869-08-7
- Biperiden CAS number 514-65-8
- Orphenadrine CAS number 83-98-7
- Carbamazepine CAS number 298-46-4
- Hydroxyzine CAS number 68-88-2
- Trihexyphenidyl CAS number 144-11-6
