CNS-agents-monitoring
INTRODUCTION
There are many different types of drugs that affect the central nervous system (CNS), including anesthetics, anticonvulsants, antiemetics, antiparkinson agents, CNS stimulants, muscle relaxants, narcotic analgesics and sedatives. Their control is important for therapeutic monitoring and in toxicologic purposes. The developed LC/MS method provides the accurate determination of a wide range of CNS agents.
ABSTRACT
LC-MS full-scan determination of a wide panel of 48 central nervous system (CNS) agents (anaesthetics, anticonvulsants, antiemetics, antiparkinson agents, CNS stimulants, muscle relaxants, narcotic analgesics and sedatives) on an ASTRA® C18-HE 3.0 µm column, 75 mm × 2.1 mm, part number AST-5732-IH21. Mobile phase A is DDW + 0.1% formic acid and mobile phase B is ACN + 0.1% formic acid. Gradient elution (time / A% / B%): 0 / 90 / 10, 1 / 90 / 10, 4 / 75 / 25, 8 / 60 / 40, 10 / 0 / 100, 14 / 0 / 100, 14.01 / 90 / 10, 15 / 90 / 10, 17 / 90 / 10. Flow rate 0.35 mL/min, column temperature 23 °C, injection volume 5 µL, detection by full scan (resolving power 120 000 at m/z 200) in positive mode. Analytes with CAS numbers as printed: 1. gabapentin 60142-96-3, 2. terbutaline 23031-25-6,…
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Astra C18-HE
Part number
AST-5732-IH21
Analytes
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- Vortioxetine CAS number 508233-74-7
- Oxazepam CAS number 604-75-1
- Cyproheptadine CAS number 129-03-3
- Diclofenac CAS number 15307-86-5
- Pizotifen (pizotyline) CAS number 15574-96-6
- Levomepromazine CAS number 60-99-1
- Amitriptyline CAS number 50-48-6
- Maprotiline CAS number 10262-69-8
- Venlafaxine CAS number 93413-69-5
- Nefazodone CAS number 83366-66-9
