CNS-agents-monitoring
INTRODUCTION
There are many different types of drugs that affect the central nervous system (CNS), including anesthetics, anticonvulsants, antiemetics, antiparkinson agents, CNS stimulants, muscle relaxants, narcotic analgesics and sedatives. Their control is important for therapeutic monitoring and in toxicologic purposes. The developed LC/MS method provides the accurate determination of a wide range of CNS agents.
ABSTRACT
LC-MS full-scan determination of a wide panel of 48 central nervous system (CNS) agents (anaesthetics, anticonvulsants, antiemetics, antiparkinson agents, CNS stimulants, muscle relaxants, narcotic analgesics and sedatives) on an ASTRA® C18-HE 3.0 µm column, 75 mm × 2.1 mm, part number AST-5732-IH21. Mobile phase A is DDW + 0.1% formic acid and mobile phase B is ACN + 0.1% formic acid. Gradient elution (time / A% / B%): 0 / 90 / 10, 1 / 90 / 10, 4 / 75 / 25, 8 / 60 / 40, 10 / 0 / 100, 14 / 0 / 100, 14.01 / 90 / 10, 15 / 90 / 10, 17 / 90 / 10. Flow rate 0.35 mL/min, column temperature 23 °C, injection volume 5 µL, detection by full scan (resolving power 120 000 at m/z 200) in positive mode. Analytes with CAS numbers as printed: 1. gabapentin 60142-96-3, 2. terbutaline 23031-25-6,…
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Astra C18-HE
Part number
AST-5732-IH21
Analytes
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- Trazodone CAS number 19794-93-5
- Amisulpride CAS number 71675-85-9
- Duloxetine CAS number 116539-59-4
- Cetirizine CAS number 83881-51-0
- Fexofenadine CAS number 83799-24-0
- Memantine CAS number 19982-08-2
- rac trans-10,11-Dihydro-10,11-dihydroxy Carbamazepine CAS number 176486-10-5
- Primidone CAS number 125-33-7
