Hormones-receptors-agents
INTRODUCTION
Hormones are responsible for carrying out various functions in the human body. A treatment of lot of diseases is based on hormones receptor – targeted agent interaction. In this application is shown a precise lc/ms method for analysis of drugs agents finasteride, tamoxifen, used in cancer therapy, and beclomethasone, well known agent for asthma managment.
ABSTRACT
LC-MS full-scan determination of three hormone-receptor–targeted agents — finasteride, tamoxifen (both used in cancer therapy) and beclomethasone (an asthma agent) — on an ASTRA® C18-HE 3 µm column, 75 mm × 2.1 mm, part number AST-5732-IH21. Mobile phase A is DDW + 0.1% formic acid and mobile phase B is ACN + 0.1% formic acid. Gradient elution (time / A% / B%): 0 / 90 / 10, 1 / 90 / 10, 4 / 75 / 25, 8 / 60 / 40, 10 / 0 / 100, 14 / 0 / 100, 14.01 / 90 / 10, 15 / 90 / 10, 17 / 90 / 10. Flow rate 0.35 mL/min, column temperature 23 °C, injection volume 5 µL, detection by full scan (resolving power 120 000 at m/z 200) in positive mode. Analytes with CAS numbers as printed: 1. finasteride, CAS number 98319-26-7, 2. tamoxifen, CAS number 10540-29-1, 3. beclomethasone, CAS number 4419…
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Astra C18-HE
Part number
AST-5732-IH21
Analytes
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- Finasteride CAS number 98319-26-7
- Tamoxifen CAS number 10540-29-1
- Beclomethasone CAS number 4419-39-0
