Acetylsalicyclic acid
INTRODUCTION
Acetylsalicylic acid is very well-known as the drug Aspirin and is used to reduce pain and fever. It is also supplied under other brand names, such as Acylpyrin or Anopyrin. This application note shows the determination of impurity – salicyclic acid in the final product.
ABSTRACT
Determination of the salicylic acid impurity (CAS 69-72-7) in acetylsalicylic acid (CAS 50-78-2) on an ARION® Polar C18, 5 µm column (250 mm × 4.6 mm, ARI-5721-LM46). Isocratic proprietary elution with sodium 1-heptanesulfonate / acetonitrile and acetic acid at 2.0 ml/min and 25 °C, injection 10 µl, UV detection at 280 nm. Compared with a competitive C18 column (Competitor S), the ARION® Polar C18 gives longer retention and a wider gap between the impurity and the main peak.
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Arion Polar C18
Part number
ARI-5721-LM46
Analytes
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique. Duis cursus, mi quis viverra ornare, eros dolor interdum nulla. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros.w
- Salicylic acid CAS number 69-72-7
- Acetylsalicylic acid CAS number 50-78-2
