Voriconazole and Posaconazole are antifungal drugs that are monitored in plasma and urine. Spiked samples based on a blood plasma from blood donors at transfusion station were used in this application note.
ABSTRACT
Therapeutic drug monitoring of voriconazole (VRC, CAS 137234-62-9) and posaconazole (PSC, CAS 171228-49-2) in blood plasma with clopazin as internal standard, on an ARION® Plus C18, 5 µm column (150 mm × 4.6 mm, ARI-5720-LK46). Isocratic elution with 0.01 M TEMED pH = 7.4 / ACN 30/70 (v/v) at 1.5 ml/min and 27 °C, UV detection at 254 nm (ref. 360 nm). The whole run takes under 3 minutes. The note shows a standard (5.0 mg/l VRC, 3.0 mg/l PSC), plasma spiked at 0.4/0.2 and 2.0/1.2 mg/l and a sample from a patient under posaconazole treatment. Author of this application: Department of Clinical Biochemistry, University Hospital Brno.
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Voriconazole (VRC)CAS number 137234-62-9
Posaconazole (PSC)CAS number 171228-49-2
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University Hospital Brno
One of the largest hospitals in the Czech Republic. Its Department of Clinical Biochemistry runs routine and specialised analyses including therapeutic drug monitoring of antifungal and other drugs in plasma and urine.
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