Triazoles
INTRODUCTION
Triazoles are used as intermediates for API production. This application shows the separation of all triazoles in one analysis.
ABSTRACT
Isocratic HPLC/DAD separation of four triazole intermediates – TCA / 1,2,4-triazole-3-carboxylic acid (CAS 4928-87-4), TAM / 2H-1,2,4-triazole-3-carboxamide (CAS 3641-08-5), TME / methyl 1H-1,2,4-triazole-3-carboxylate (CAS 4928-88-5) and TCN / 3-cyano-1,2,4-triazole (CAS 3641-10-9) – on an ASTRA® DM, 3 µm column (150 mm × 4.6 mm, AST-5810-IK46). Isocratic elution with 2 mM ammonium formate + 0.1% formic acid, pH 2.83 : methanol 90/10 (v/v) at 1.0 ml/min and 25 °C, injection volume 1 µl, DAD detection at 210 nm. All four analytes are resolved within about 5 minutes.
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Astra DM
Part number
AST-5810-IK46
Analytes
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- TCA (1,2,4-Triazole-3-carboxylic acid) CAS number 4928-87-4
- TAM (2H-1,2,4-Triazole-3-carboxamide) CAS number 3641-08-5
- TME (Methyl 1H-1,2,4-triazole-3-carboxylate) CAS number 4928-88-5
- TCN (3-Cyano-1,2,4-triazole) CAS number 3641-10-9
