Biphenols by online SPE and LC-MSMS
INTRODUCTION
Based on the toxicity of bisphenols to human health and aquatic ecosystem, BPA and its analogues should be strictly controlled in different environmental matrices at low concentrations. The sample preparation step is time-consuming and critical for analytical determination of BPs due to complex analytes pre-concentrating. Online SPE-LC-MS/MS method provides sensitive, effective, rapid, and simple extraction and analysis of bisphenols in water sample matrix.
ABSTRACT
Online SPE-LC-MS/MS method for the sensitive, rapid extraction and determination of bisphenols in water sample matrix. The online SPE (loading) column is an ASTRA® C18 AQ 10 µm, 30 mm × 2.1 mm, part number AST-5832-PD21 (loading time 0–3 min); the analytical column is an ASTRA® C18 AQ 5 µm, 50 mm × 2.1 mm, part number AST-5832-LG21 (elution time 3–20 min). Mobile phase A is DDW and mobile phase B is MeOH. Gradient elution (time min / A% / B% / flow rate µL/min): 0 / 100 / 0 / 450, 1 / 100 / 0 / 1500, 3 / 100 / 0 / 1500, 3.05 / 100 / 0 / 450, 6 / 100 / 0 / 450, 10 / 0 / 100 / 450, 15 / 0 / 100 / 450, 15.05 / 100 / 0 / 450, 20 / 100 / 0 / 450. Column temperature 23 °C, injection volume 1 mL, detection online SPE-LC-MS/MS in negative MRM mode; MS instrument Bruker EVOQ® DART-TQ+;…
Industries
Environmental
Category
HPLC columns
Product
Astra C18-AQ
Part number
AST-5832-PD21
AST-5832-LG21
Analytes
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- Bisphenol S CAS number 80-09-1
- Bisphenol F CAS number 620-92-8
- Bisphenol A CAS number 80-05-7
- Bisphenol B CAS number 77-40-7
- Bisphenol AF CAS number 1478-61-1
