Residual solvents
INTRODUCTION
Residual solvents control is a mandatory test for active pharmaceutical ingredients. Column LION™ LN-1 provides fast, robust and reproducible separation for most commonly used solvents.
ABSTRACT
Head-space GC/FID method for the control of residual solvents in active pharmaceutical ingredients – methanol (CAS 67-57-1), ethanol (CAS 64-17-5), acetone (CAS 67-64-1), 1-propanol (CAS 71-23-8) and toluene (CAS 108-88-3) – on a LION™ LN-1 capillary column (50 m × 0.25 mm × 5 µm, LNI-5755-H150). Injection temperature 160 °C, helium carrier gas at constant pressure 60 kPa (40 ml/min), oven program 40 °C hold 0 min; 2 °C/min to 60 °C; 50 °C/min to 200 °C hold 5 min. Solvent dimethylsulfoxide, head-space oven 105 °C with 30 min heating, FID detection at 250 °C. All five solvents are resolved within about 14 minutes.
Industries
Pharma & Veterinary Drugs
Category
GC columns
Product
Lion 1
Part number
LNI-5755-H150
Analytes
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique. Duis cursus, mi quis viverra ornare, eros dolor interdum nulla. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros.w
- Methanol CAS number 67-57-1
- Ethanol CAS number 64-17-5
- Acetone CAS number 67-64-1
- 1-Propanol CAS number 71-23-8
- Toluene CAS number 108-88-3
