Opioids APIs
INTRODUCTION
Opioids can be used in medicine to treat pain and to manage withdrawal symptoms. ASTRA® Phenyl-Hexyl-HE column allows to separate the mixture of opioids with sufficient resolution coefficients in comparison to competitive's column.
ABSTRACT
Isocratic HPLC/UV separation of seven opioid APIs – morphine (CAS 57-27-2), oripavine (CAS 467-04-9), codeine (CAS 76-57-3), naltrexone (CAS 16590-41-3), nalmefene (CAS 55096-26-9), thebaine (CAS 115-37-7) and nalbuphine (CAS 20594-83-6) – on an ASTRA® Phenyl-Hexyl-HE, 5.0 µm column (250 mm × 4.6 mm, AST-5891-LM46). Mobile phase TEA : 50 % MeOH + 0.2 % H3PO4 (pH = 7.0), isocratic elution at 1.0 mL/min and 30 °C, injection volume 20 µL, UV detection at 230 nm. All seven opioids are resolved within about 25 minutes, with better resolution than on the competitive column (Competitor R), where peaks 6 and 7 elute close together.
Industries
Pharma & Veterinary Drugs
Category
HPLC columns
Product
Astra Phenyl-Hexyl HE
Part number
AST-5891-LM46
Analytes
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- Morphine CAS number 57-27-2
- Oripavine CAS number 467-04-9
- Codeine CAS number 76-57-3
- Naltrexone CAS number 16590-41-3
- Nalmefene CAS number 55096-26-9
- Thebaine CAS number 115-37-7
- Nalbuphine CAS number 20594-83-6
