Prostaglandin Active Pharmaceutical Ingredients (APIs) play a significant role in the bodies of humans and animals, and therefore are synthetised for use in ophthalmology, veterinary, and vascular treatment.
ABSTRACT
Analysis of prostaglandin APIs synthetised by Cayman Pharma. A stress test on the semipreparative ARION® Si, 10 µm column (250 mm × 10 mm, ARI-5735-IK21) with 1 % IPA in DCM at 3 ml/min, ambient temperature and UV detection at 254 nm separates 1,3,5-tercbutylbenzene, acetophenon and benzophenon. The impurity profile is then run on an ARION® Plus C18, 3 µm column (150 mm × 4.6 mm, ARI-5720-IK46) with a gradient of A: ACN:H2O (50:50) and B: 90 % ACN at 1 ml/min, 40 °C and UV detection at 274 nm, resolving the main peak and nine impurities. On the core-shell (Competitor K) and fully porous (Competitor S) C18 columns several impurities coelute (3+9 and 5+6). This application was developed by Cayman Pharma Czech Republic: “Congratulations, this is probably the best semipreparative…
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique. Duis cursus, mi quis viverra ornare, eros dolor interdum nulla. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros.w
1,3,5-TercbutylbenzeneCAS number not available
AcetophenonCAS number not available
BenzophenonCAS number not available
Impurity 1CAS number not available
Impurity 5CAS number not available
Impurity 2CAS number not available
Impurity 4CAS number not available
Main peak (prostaglandin)CAS number not available
Impurity 7CAS number not available
Impurity 8CAS number not available
Partners
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros elementum tristique. Duis cursus, mi quis viverra ornare, eros dolor interdum nulla. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Suspendisse varius enim in eros.w
Cayman Pharma
Cayman Pharma is a Czech pharmaceutical manufacturer based in Neratovice, specialised in the synthesis of prostaglandin active pharmaceutical ingredients for ophthalmology, veterinary and vascular treatment.
Try&Buy
Try a product on your own instrument before you buy it. Fill in the form below and we will get back to you.
Application Request
Haven't found a suitable application for your analysis? Tell us what you need and our specialists will develop one for you.
We value your privacy
We and our digital partners use cookies on this website. Some of them are necessary for the functionality of the website, but you can decide on the following cookies yourself.
Settings
Decline all
Accept all
Necessary/functional
It would not be possible to operate the website without these cookies. They include, for example, cookies for storing selected settings or remembering logins.
Always active
Analytics
These cookies are used to measure and analyze traffic to our website (number of visitors, pages viewed, average browsing time, etc.). By consent, you will allow us to obtain data on how you use our site.
Advertisement
They are used for the purposes of advertisements displayed on third-party websites, including social networks and contextual advertising. They are tailored to your preferences and help us measure the effectiveness of our advertising campaigns. If you disable them, your ad will continue to show as you browse, but it will not be tailored to you and will be less relevant to you.
